Product of Hawaii

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We live in a world where people
suffer from brain health issues
more & more frequently... Regardless of age! Historically forgetfulness and
brain fog was for “older” people.
Mamaki Memory™ helps support 
memory,
recall and focus,
while decreasing brain fog. 

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Hear the stories of our elders..​​ Explore the healing properties of our botanical treasures…

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Mamaki is a local endemic plant of Hawaii. ​

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Mamaki (Pipturus Albidus) is indigenous to Hawaii and cannot be found anywhere else in the world. Known for its healing benefits, Mamaki is typically made into an herbal tea or tonic.

In Hawaii, the Mamaki plant, particularly ​its fruits, has a history as a local indigenous medicine ​that regulates blood glucose levels, blood pressure, ​and cholesterol levels; relieves stress and fatigue; and ​reduces inflammation. Typically prepared as an herbal tea.​

Chun MN. Mamaki. In: Native Hawaiian medicines. Honolulu, HI:​First People’s Productions; 1994

Mamaki leaves contain polyphenols, catechin, chlorogenic acid, and rutin​.

Kartika H, Li QX, Wall MM, Nakamoto ST, Iwaoka WT. Major phenolic acids and total antioxidant activity in Mamaki leaves. Pipturus albidus J Food Sci. 2007;72(9):S696-701. https://doi.org/10.1111/j.1750- 3841.2007.00530.x.​

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Used in traditional Hawaiian medicine for centuries

Polyphenols have multiple functions such as anti-inflammatory, antioxidizing, and show beneficial effects against neurodegenerative diseases in model mice and humans​.

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Remember

Mamaki, a local endemic plant of Hawaii. ​

Mamaki™ may Improve Brain Function through ​increased brain function, fighting fatigue, depression & Insomnia.​ Stimulate brain activity: Catechins are polyphenols that stimulate brain activity and boost metabolic rates, exhibiting energizing, detoxifying, and mood-boosting properties. ​ These polyphenols have been shown to possess possible beneficial effects against neurodegenerative diseases in humans. ​ Recent University studies in Japan have shown the efficacy and benefits of the polyphenols in a dried blend of the plant surpassed levels of liquid Mamaki tea.​​​

Remember Mamaki, a local endemic plant of Hawaii. ​

It's important to note that traditional plant remedies should not replace professional advice. It is essential to exercise caution and consult with healthcare professionals before considering the use of any herbal remedies or natural treatment.

† This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Research

Polyphenols have been shown to possess possible beneficial effects against neurodegenerative diseases in humans.

- Afzal O, Dalhat MH, Altamimi ASA, Rasool R, Alzarea SI, Almalki WH, Murtaza BN, Iftikhar S, Nadeem S, Nadeem MS, Kazmi I. Green tea catechins attenuate neurodegenerative diseases and cognitive defcits. Molecules. 2022;27(21):7604. https://doi.org/10.3390/molecules2 7217604.​

 - Payne A, Nahashon S, Taka E, Adinew GM, Soliman KFA. Epigallocatechin-3-gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age. Biomolecules. 2022;12(3):371. https://doi.org/10.3390/biom12030371.

​ - Li Q, Zhao HF, Zhang ZF, Liu ZG, Pei XR, Wang JB, Cai MY, Li Y. Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade. Neuroscience. 2009;159(4):1208–15. https://doi.org/10.1016/j.neuroscience.2009.02.008.​

 - Yoo KY, Choi JH, Hwang IK, Lee CH, Lee SO, Han SM, Shin HC, Kang IJ, Won MH. (-)-Epigallocatechin-3-gallate increases cell proliferation and neuroblasts in the sub-granular zone of the dentate gyrus in adult mice. Phytother Res. 2010;24(7):1065–70. https://doi.org/10.1002/ptr.3083. ​- Socała K, Szopa A, Serefko A, Poleszak E, Wlaź P. Neuroprotective efects of cofee bioactive compounds: A review. Int J Mol Sci. 2020;22(1):107. https://doi.org/ 10.3390/ijms22010107​

 - Gao L, Li X, Meng S, Ma T, Wan L, Xu S. Chlorogenic acid alleviates Aβ25–35-induced autophagy and cognitive impairment via the mTOR/TFEB signaling pathway. Drug Des Devel Ther. 2020;14:1705–16. https://doi.org/10.2147/DDDT.S235969.​

 - Singh SS, Rai SN, Birla H, Zahra W, Rathore AS, Dilnashin H, Singh R, Singh SP. Neuroprotective effect of chlorogenic acid on mitochondrial dysfunction-mediated apoptotic death of DA neurons in a Parkinsonian mouse model. Oxid Med Cell Longev. 2020;2020:6571484. https://doi.org/10.1155/2020/6571484

​ - Liu D, Wang H, Zhang Y, Zhang Z. Protective effects of chlorogenic acid on cerebral ischemia/reperfusion injury rats by regulating oxidative stress-related Nrf2 pathway. Drug Des Devel Ther. 2020;14:51–60. https://doi.org/10.2147/DDDT.S228751​ - Tahir MS, Almezgagi M, Zhang Y, Bashir A, Abdullah HM, Gamah M, Wang X, Zhu Q, Shen X, Ma Q, Ali M, Solangi ZA, Malik WS, Zhang W. Mechanistic new insights of flavonols on neurodegenerative diseases. Biomed Pharmacother. 2021;137:111253. https://doi.org/10.1016/j.biopha.2021.111253​

 - Xu PX, Wang SW, Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ, Liu RT. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by ​reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;1(264):173–80. https://doi.org/10.1016/j.bbr.2014.02.002.​

 - Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT. Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease. ​Neuroinflammation. 2021;18(1):131. https://doi.org/10.​1186/s12974-021-02182-3.

- Moghbelinejad S, Nassiri-Asl M, Farivar TN, Abbasi E, Sheikhi M, Taghiloo M, Farsad F, Samimi A, Hajiali F. Rutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced neurotoxicity in rats. Toxicol Lett. 2014;224(1):108–13. https://doi.org/10.1016/j.toxlet.2013.10.010​

 - Journal: GeroScience​Title: Hawaiian native herb Mamaki prevents dementia by ameliorating neuropathology and repairing neurons in four different mouse models of neurodegenerative diseases​Authors: Tomohiro Umeda, Keiko Shigemori, Rumi Uekado, Kazunori Matsuda, Takami Tomiyama* *Department of Translational Neuroscience, Osaka Metropolitan University ​Graduate School of Medicine​

Make more memories… Mamaki Memory™

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Live Memorably

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Confidence

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Focus

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Improves Recall

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Anti-inflammatory

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A portion of sales ​is earmarked for local entities​ assisting in land and housing ​for indigenous people.​

Your purchase of Mamaki Memory will help create funds to assist ​resettling land, and/or build dwellings for indigenous peoples.​

BACKGROUND

Mike Nakamura currently resides in Hawaii, running his small farm of orchards and herbs. A 5th generation descendant of the famous herbalist Koun Nakamura of Takaya-cho, Okayama, Japan. It was around the time of a visit to the family cemetery in 2023 along with other serendipitous events that Mamaki Memory ™ was born.​

Koun Nakamura,
Renowned Herbalist.
Takaya - cho, Okayama, Japan

...local plants, local remedies, for local people

- Koun Nakamura Herbalist (1797 - 1865)

PLANT medicine is natures script for wellness, ancient wisdom for modern health.

https://core.ac.uk/reader/233216050

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